Drug interactions between phenobarbital and Sandimmune
Results for the following 2 drugs: |
|
|---|---|
| phenobarbital | |
| Sandimmune (cyclosporine) | |
Interactions between your selected drugs
cyclosporine ⇔ phenobarbital
Applies to: Sandimmune (cyclosporine) and phenobarbital
MONITOR: Barbiturates may decrease serum cyclosporine concentrations and efficacy. The mechanism is enhanced hepatic microsomal metabolism of cyclosporine. A case report has described this interaction for phenobarbital; however, the barbiturates are known enzyme inducers. Effects may not be apparent until 1 to 2 weeks after the barbiturate is added to the regimen or its dose is changed.
MANAGEMENT: If these agents must be used together, close observation for clinical and laboratory evidence of decreased cyclosporine effect is indicated, particularly when the dosage of either drug is added, discontinued, or changed. Alternatively, a benzodiazepine may be used, if clinically appropriate.
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