Drug interactions between oxcarbazepine and Plavix
| Results for the following 2 drugs: |
|---|
| oxcarbazepine |
| Plavix (clopidogrel) |
Interactions between your selected drugs
clopidogrel ↔ oxcarbazepine
Applies to:Plavix (clopidogrel) and oxcarbazepine
GENERALLY AVOID: Coadministration with inhibitors of CYP450 2C19 may reduce the efficacy of clopidogrel, whose antiplatelet effect is dependent in part on bioactivation by the isoenzyme to a pharmacologically active metabolite. This is consistent with studies that reported decreased effectiveness of clopidogrel and poorer clinical outcome in patients who have common genetic polymorphisms of CYP450 2C19 resulting in reduced or absent enzyme activity. The interaction has been studied with omeprazole, a potent CYP450 2C19 inhibitor. In 72 healthy subjects administered clopidogrel (300 mg loading dose followed by 75 mg/day) alone and with omeprazole (80 mg) simultaneously for 5 days, systemic exposure to the active metabolite of clopidogrel decreased by 46% (Day 1) and 42% (Day 5) during coadministration with omeprazole, while mean inhibition of platelet aggregation (IPA) diminished by 47% (24 hours) and 30% (Day 5). Similar results were reported when the same doses of clopidogrel and omeprazole were administered 12 hours apart in another study.
MANAGEMENT: Based on existing data, patients treated with clopidogrel should avoid the concomitant use of drugs that are inhibitors of CYP450 2C19 such as omeprazole, cimetidine, delavirdine, efavirenz, etravirine, felbamate, fluoxetine, fluvoxamine, fluconazole, isoniazid, ketoconazole, letrozole, moclobemide, modafinil, oxcarbazepine, ticlopidine, and voriconazole.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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