Drug interactions between Ocella and Topamax
| Results for the following 2 drugs: |
|---|
| Ocella (drospirenone/ethinyl estradiol) |
| Topamax (topiramate) |
Interactions between your selected drugs
ethinyl estradiol ↔ topiramate
Applies to:Ocella (drospirenone/ethinyl estradiol) and Topamax (topiramate)
ADDITIONAL CONTRACEPTION RECOMMENDED: Efficacy of oral contraception may be decreased by concomitant use with topiramate. The mechanism of action appears to be increased metabolism of the estrogenic component of the oral contraceptive. In a pharmacokinetic study with topiramate 800 mg/day, ethinyl estradiol clearance increased by 47% (range 13% to 107%), while norethindrone was unaffected. Although this has not been reported with mestranol, the likelihood of an interaction should be considered.
MANAGEMENT: Patients taking oral contraceptives and topiramate should be warned of the potential for decreased efficacy of the oral birth control, counseled about the use of additional pregnancy prevention methods, and advised to report any changes in bleeding patterns to their clinician. Some experts have recommended a higher dose contraceptive; however, no specific recommendations are available. Intrauterine systems are unlikely to be significantly affected because of their local action.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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