Drug interactions between Miradon and Mycifradin
| Results for the following 2 drugs: |
|---|
| Miradon (anisindione) |
| Mycifradin (neomycin) |
Interactions between your selected drugs
neomycin ↔ anisindione
Applies to:Mycifradin (neomycin) and Miradon (anisindione)
MONITOR: Limited data suggest that the effect of oral anticoagulants may be increased in patients also receiving oral neomycin. Increases in INR are possible. The exact mechanism is unknown but may involve depletion of certain clotting factors due to suppression of vitamin K-producing intestinal flora and inhibition of vitamin K absorption. Clinical data have been conflicting. Significant changes are not expected in patients with normal dietary intake of vitamin K.
MANAGEMENT: The clinician may consider closer INR and clinical monitoring in patients starting or stopping neomycin therapy while also receiving oral anticoagulants. The dose of the oral anticoagulant may need to be adjusted. Patients should be advised to promptly report any signs of bleeding to their doctor, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, nosebleeds, bleeding of gums from brushing, red or brown urine, or red or black stools.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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