Drug interactions between metoprolol and Rythmol SR
Results for the following 2 drugs: |
|
|---|---|
| metoprolol | |
| Rythmol SR (propafenone) | |
Interactions between your selected drugs
metoprolol ⇔ propafenone
Applies to: metoprolol and Rythmol SR (propafenone)
MONITOR: Propafenone may significantly increase serum levels and effects of some oral beta-blockers. The proposed mechanism is inhibition of CYP450 2D6 first-pass metabolism and decreased hepatic clearance. Data are available for metoprolol and propranolol only; however, other hepatically metabolized oral beta-blockers may also be affected. Renally excreted beta-blockers such as atenolol, carteolol, nadolol, or sotalol are not expected to interact. In addition, negative inotropic effects may be potentiated.
MANAGEMENT: Patients receiving this combination should be monitored for hypotension, heart failure, bradycardia, arrhythmias, and mental status changes. Beta-blocker dosage may be decreased if necessary.
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