Drug interactions between metformin and Tagamet
| Results for the following 2 drugs: |
|---|
| metformin |
| Tagamet (cimetidine) |
Interactions between your selected drugs
cimetidine ↔ metformin
Applies to:Tagamet (cimetidine) and metformin
MONITOR: Cimetidine may significantly reduce the renal tubular secretion of metformin. In one study, the area under the plasma concentration-time curve for metformin was increased by 50% and the plasma clearance was reduced by 27%. Increased metformin levels may increase the risk of lactic acidosis.
MANAGEMENT: Particularly slow and cautious titration of metformin dosage is recommended if these drugs must be used together. The maximal dose of metformin should also be reduced until further information about this interaction is available. Patients should be advised to monitor their blood glucose and to promptly notify their physician if they experience possible signs of lactic acidosis such as nausea, vomiting, malaise, myalgia, weakness, respiratory distress, slow or irregular heartbeat, dizziness, lightheadedness, or other unusual symptoms.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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