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Drug Interactions between melatonin and methoxsalen

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

methoxsalen melatonin

Applies to: methoxsalen and melatonin

Methoxsalen may increase the blood levels of melatonin. You may experience increased side effects such as excessive drowsiness, headache, lethargy, dizziness, irritability, nervousness, restlessness, anxiety, abdominal pain, and upset stomach. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

methoxsalen food

Applies to: methoxsalen

Methoxsalen should be administered with food or milk. This may make it easier for your body to tolerate the medication. Avoid eating or coming in contact with limes, figs, parsley, parsnips, rue (Ruta graveolens), mustard, carrots and celery. This can increase the risk of photosensitivity and cause your skin to burn more easily. Avoid prolonged exposure to sunlight, sunlamps, or tanning beds. Methoxsalen make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use a sunscreen if you must be in the sun. Call your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.

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Moderate

melatonin food

Applies to: melatonin

Both smoking and excessive caffeine consumption can alter the blood levels of melatonin, which may affect the dosing. Tobacco smoking reduces, while caffeine increases melatonin blood levels. If you start smoking or undergo smoking cessation, your doctor may need to adjust the dose of melatonin. In addition, alcohol may reduce the effect of melatonin on sleep. It is best to avoid alcohol consumption during melatonin therapy. Talk to a healthcare professional if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer