Drug Interactions between mefloquine and nitazoxanide
This report displays the potential drug interactions for the following 2 drugs:
- mefloquine
- nitazoxanide
Interactions between your drugs
mefloquine nitazoxanide
Applies to: mefloquine and nitazoxanide
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with nitazoxanide may increase the free plasma concentrations of drugs and/or their active metabolites that are highly bound to plasma proteins. The pharmacologic effects of some drugs may be increased by this interaction. The proposed mechanism is competitive displacement from protein binding sites by tizoxanide, the active metabolite of nitazoxanide that is greater than 99.9% bound to plasma proteins.
MANAGEMENT: Caution is advised when other highly protein-bound drugs are used with nitazoxanide, particularly those with a narrow therapeutic index. Patients should be monitored more closely following the addition or withdrawal of nitazoxanide. When performing therapeutic drug monitoring, total plasma concentrations should be interpreted cautiously due to the possibility of increased free (unbound) drug.
References
- "Product Information. Alinia (nitazoxanide)." Romark Laboratories L.C. (2002):
Drug and food interactions
mefloquine food
Applies to: mefloquine
Food can enhance the levels of mefloquine in your body. Take mefloquine immediately after a meal. This will make it easier for your body to absorb the medication. Take each dose with a full glass, at least 8 ounces (240 mL) of water. For children or those who have difficulty swallowing, mefloquine can be crushed and mixed with water or sugar water. Talk to your healthcare provider if swallowing the tablets is difficult.
nitazoxanide food
Applies to: nitazoxanide
Food can enhance the levels of nitazoxanide in your body. Nitazoxanide should be taken just after eating food. Do not take it on an empty stomach. This will make it easier for your body to absorb the medication.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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