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Drug Interactions between lurbinectedin and Provigil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

modafinil lurbinectedin

Applies to: Provigil (modafinil) and lurbinectedin

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with a moderate CYP450 3A4 inducer may decrease the systemic exposure (AUC) of lurbinectedin, which is metabolized by the isoenzyme in vitro. In a clinical drug interaction study, coadministration of bosentan, a moderate CYP450 3A4 inducer, decreased the AUC of total lurbinectedin by 20% and unbound lurbinectedin by 19%. According to the lurbinectedin prescribing information, these changes are not considered clinically relevant.

MANAGEMENT: Clinical and laboratory monitoring is advised whenever a moderate CYP450 3A4 inducer is added to or withdrawn from lurbinectedin therapy.

References

  1. "Product Information. Zepzelca (lurbinectedin)." Jazz Pharmaceuticals (2020):

Drug and food interactions

Major

lurbinectedin food

Applies to: lurbinectedin

Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with lurbinectedin unless directed otherwise by your doctor. Grapefruit juice may increase the blood levels of lurbinectedin. This may increase side effects such as liver problems and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Minor

modafinil food

Applies to: Provigil (modafinil)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer