Drug interactions between lithium and Tofranil
| Results for the following 2 drugs: |
|---|
| lithium |
| Tofranil (imipramine) |
Interactions between your selected drugs
lithium ↔ imipramine
Applies to:lithium and Tofranil (imipramine)
MONITOR: The concomitant use of lithium and tricyclic antidepressants (TCAs) may potentiate the risk of neurotoxicity and psychotic symptoms, even at therapeutic serum lithium levels. The mechanism is unknown but may be related to synergistic effects on neurotransmission. Mania, myoclonus, tremors, memory difficulties, confusion, serotonin syndrome, and a neuroleptic malignant-like syndrome have been reported in patients treated with TCAs several days after the addition of lithium, in most cases requiring discontinuation of either the TCA or lithium. Elderly patients may be particularly susceptible to this interaction.
MANAGEMENT: Close monitoring for symptoms of neurotoxicity is recommended if TCAs are used with lithium. Dosage adjustment or discontinuation of one or both drugs may be necessary if an interaction is suspected.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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