Drug Interactions

Drug interactions between lithium and Stelazine

Results for the following 2 drugs:

lithium
Stelazine (trifluoperazine)

Interactions between your selected drugs

lithium ⇔ trifluoperazine

Applies to: lithium and Stelazine (trifluoperazine)

MONITOR: Although lithium and phenothiazines are frequently used together in the setting of acute mania, concurrent administration may induce a number of neurologic and psychiatric effects (despite decreased phenothiazine levels during lithium therapy). Mental status changes, delirium, seizures, extrapyramidal effects, fever, and other symptoms have been reported. The mechanism is unknown.

MANAGEMENT: Patients receiving lithium and a phenothiazine should be closely monitored for altered efficacy and safety. In some circumstances, discontinuation of one or both agents may be necessary.

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