Drug interactions between interferon alfa-2a and Miradon
| Results for the following 2 drugs: |
|---|
| interferon alfa-2a |
| Miradon (anisindione) |
Interactions between your selected drugs
anisindione ↔ interferon alfa-2a
Applies to:Miradon (anisindione) and interferon alfa-2a
MONITOR: Interferons may increase the plasma concentrations and pharmacologic effects of warfarin and other oral anticoagulants. At least one case of this interaction has been reported in the literature. The mechanism is unknown but may be related to interferon-induced suppression of hepatic CYP450 enzymes. Physiologic events and drugs that induce interferon synthesis (e.g., viral infection, influenza vaccination) have also been reported to decrease metabolism and potentiate the effects of certain drugs including warfarin.
MANAGEMENT: Caution is advised if oral anticoagulants are administered with an interferon. The INR should be monitored closely and anticoagulant dosage adjusted accordingly, particularly following initiation or discontinuation of interferon therapy in patients who are stabilized on their anticoagulant regimen. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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