Drug interactions between Humulin N and metformin
| Results for the following 2 drugs: |
|---|
| Humulin N (insulin isophane) |
| metformin |
Interactions between your selected drugs
metformin ↔ insulin isophane
Applies to:metformin and Humulin N (insulin isophane)
MONITOR: Metformin can potentiate the hypoglycemic effects of insulin. The mechanism may involve either increases in cellular mechanisms controlled by insulin or effects on complementary biochemical reactions. While this interaction can be used to clinical advantage, clinicians should be aware that coadministration of metformin increases the risk of hypoglycemia associated with insulin.
MANAGEMENT: Close monitoring for the development of hypoglycemia is recommended if metformin is coadministered with insulin, particularly in patients with advanced age and/or renal impairment. Patients should be apprised of the signs and symptoms of hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, hunger, tremor, weakness, sweating, palpitations), how to treat it, and to contact their physician if it occurs.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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