Drug interactions between gefitinib and Miradon
| Results for the following 2 drugs: |
|---|
| gefitinib |
| Miradon (anisindione) |
Interactions between your selected drugs
anisindione ↔ gefitinib
Applies to:Miradon (anisindione) and gefitinib
MONITOR: Coadministration with gefitinib has resulted in INR elevations and/or bleeding events in some patients taking warfarin. The mechanism of interaction has not been established, and it is not known whether other oral anticoagulants are similarly affected.
MANAGEMENT: Given the potential for interaction and the high degree of interpatient variability with respect to warfarin metabolism, patients should be closely monitored during concomitant therapy with gefitinib. The INR should be checked frequently and warfarin dosage adjusted accordingly, particularly following initiation or discontinuation of gefitinib in patients who are stabilized on their warfarin regimen. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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