Drug interactions between Felbatol and valproic acid
Results for the following 2 drugs: |
|
|---|---|
| Felbatol (felbamate) | |
| valproic acid | |
Interactions between your selected drugs
valproic acid ⇔ felbamate
Applies to: valproic acid and Felbatol (felbamate)
ADJUST DOSE: Felbamate may increase steady-state plasma concentrations of valproate by decreasing its plasma clearance.
MANAGEMENT: When combination therapy involving felbamate and valproic acid or its derivatives is initiated, valproate dosage generally should be decreased 20% to 30%. Lower felbamate dosages may also be required. Close observation for clinical and laboratory evidence of altered effects is indicated, especially when changing the dose or discontinuing felbamate. Patients should be advised to report possible symptoms of valproate toxicity to their physician, including nausea, confusion, irritability, nervousness, restlessness, tremor, insomnia, headache, or somnolence.
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