Drug interactions between Felbatol and phenobarbital
Results for the following 2 drugs: |
|
|---|---|
| Felbatol (felbamate) | |
| phenobarbital | |
Interactions between your selected drugs
phenobarbital ⇔ felbamate
Applies to: phenobarbital and Felbatol (felbamate)
ADJUST DOSE: Felbamate may decrease the hepatic metabolism of phenobarbital. Phenobarbital toxicity may result. In addition, phenobarbital may induce felbamate metabolism resulting in decreased felbamate concentrations. It may take up to 1 month to reach steady state phenobarbital concentrations.
MANAGEMENT: If this combination cannot be avoided, the phenobarbital dose may require a 25% reduction. Patients should be closely monitored for clinical response and phenobarbital toxicity (drowsiness, ataxia, lethargy) for at least one month after initiating concomitant therapy. Decreased phenobarbital doses may be required if felbamate is discontinued.
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