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Drug Interactions between esketamine and ganaxolone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

esketamine ganaxolone

Applies to: esketamine and ganaxolone

Using esketamine together with ganaxolone may increase side effects such as drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. After receiving treatment with esketamine, you should avoid driving or operating hazardous machinery until the next day after a restful sleep. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

esketamine food

Applies to: esketamine

Using esketamine together with alcohol may increase side effects such as drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. You should avoid or limit the use of alcohol while being treated with esketamine. Nausea and vomiting may occur following the nasal application of esketamine. To help prevent nausea and vomiting, you should avoid eating for at least 2 hours before using esketamine and avoid drinking liquids for at least 30 minutes before using esketamine.

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Moderate

ganaxolone food

Applies to: ganaxolone

Ganaxolone must be taken with food to ensure adequate absorption of the medication. It is best to avoid or limit the consumption of alcohol, as it can increase drowsiness or other nervous system side effects of ganaxolone. You should also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer