Drug Interactions between eplerenone and vosoritide

Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be avoided during treatment with eplerenone as they may increase the blood levels and effects of eplerenone. High blood levels of eplerenone can increase the risk of side effects including hyperkalemia (high blood potassium), which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia during treatment with eplerenone if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Vosoritide may cause transient decreases in blood pressure. To reduce the risk of low blood pressure and its associated symptoms, you should have adequate food intake before vosoritide administration and should drink approximately 8 to 10 ounces of liquids within the hour prior to vosoritide injection. Tell your doctor if you experience fatigue, nausea, dizziness, or lightheadedness after vosoritide injection. Avoid driving or operating hazardous machinery until you know how this medication affects you and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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