Drug interactions between enalapril and Zostrix
| Results for the following 2 drugs: |
|---|
| enalapril |
| Zostrix (capsaicin topical) |
Interactions between your selected drugs
enalapril ↔ capsaicin
Applies to:enalapril and Zostrix (capsaicin topical)
Concomitant use of an ACE inhibitor and topical capsaicin may potentiate the cough associated with each of these agents individually. In 16 healthy volunteers, pretreatment with oral captopril (25 mg) two hours before inhalation of nebulized incremental doses of capsaicin (0.5 to 20 micromol/L in normal saline) resulted in a significant shift of the dose-response curve to capsaicin compared to pretreatment with placebo. The geometric mean dose of capsaicin causing 20 coughs per minute was 1.3 micromol/L for captopril and 2.8 micromol/L for placebo. In a case report, a 53-year-old woman who had been treated with an ACE inhibitor for several years complained of cough each time she applied a 0.075% capsaicin cream to her lower extremities. The patient had not experienced a cough during treatment with the ACE inhibitor alone. However, capsaicin alone may also induce coughing.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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