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Drug Interactions between droxidopa and isoniazid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

isoniazid droxidopa

Applies to: isoniazid and droxidopa

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Based on their mechanism of action, nonselective monoamine oxidase inhibitors (MAOIs) may potentiate the risk of supine hypertension associated with the use of droxidopa in the treatment of neurogenic orthostatic hypotension.

MANAGEMENT: Concomitant use of droxidopa with nonselective MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine) should be avoided. Selective MAO-B inhibitors such as rasagiline and selegiline were permitted in droxidopa clinical trials.

References

  1. "Product Information. Northera (droxidopa)." Chelsea Therapeutics Inc (2014):

Drug and food interactions

Moderate

isoniazid food

Applies to: isoniazid

Food decreases the levels of isoniazid in your body. Take isoniazid on an empty stomach at least 1 hour before or 2 hours after a meal. This will make it easier for your body to absorb the medication. If nausea occurs, ask your doctor if you can take isoniazid with food. Avoid alcohol while taking isoniazid. Alcohol may increase the risk of damage to the liver during isoniazid treatment. Alcohol can also cause isoniazid side effects to get worse. Contact your doctor if you experience flushing, chills, headache, nausea, vomiting, and diarrhea.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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