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Drug Interactions between Donatuss DC and Entereg

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

dihydrocodeine alvimopan

Applies to: Donatuss DC (dihydrocodeine / guaifenesin / phenylephrine) and Entereg (alvimopan)

Using alvimopan together with dihydrocodeine is not recommended. This can cause side effects such as abdominal pain, nausea, vomiting, and diarrhea. The use of alvimopan is discouraged if you have received dihydrocodeine for more than 7 consecutive days immediately prior to alvimopanadministration. Caution is advised if you have received more than 3 doses of dihydrocodeine within the week prior to surgery. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

phenylephrine food

Applies to: Donatuss DC (dihydrocodeine / guaifenesin / phenylephrine)

Both phenylephrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

alvimopan food

Applies to: Entereg (alvimopan)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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