Drug interactions between Dilantin and Felbatol
Results for the following 2 drugs: |
|
|---|---|
| Dilantin (phenytoin) | |
| Felbatol (felbamate) | |
Interactions between your selected drugs
phenytoin ⇔ felbamate
Applies to: Dilantin (phenytoin) and Felbatol (felbamate)
ADJUST DOSE: Felbamate may increase steady-state plasma concentrations of phenytoin by decreasing its plasma clearance. Also, phenytoin may increase (and may nearly double) the plasma clearance of felbamate. Other hydantoins may interact with felbamate in a similar manner.
MANAGEMENT: When combination therapy is initiated, the phenytoin dosage generally should be decreased by 20% to 30%, and the felbamate dose generally may be titrated more quickly than when felbamate is given as monotherapy. Close observation for clinical and laboratory evidence of altered effects is indicated. Patients should be advised to notify their physician if they experience symptoms of toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia.
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