Drug interactions between digoxin and Tikosyn
| Results for the following 2 drugs: |
|---|
| digoxin |
| Tikosyn (dofetilide) |
Interactions between your selected drugs
digoxin ↔ dofetilide
Applies to:digoxin and Tikosyn (dofetilide)
MONITOR: Concomitant administration of digoxin and dofetilide has been associated with a higher occurrence of torsade de pointes arrhythmia than dofetilide alone. It is not clear whether this finding represents an interaction between the drugs or the presence of more severe structural heart disease, a known risk factor for arrhythmia, in patients on digoxin. However, no increase in mortality has been observed in patients taking this combination. In a pharmacokinetic study, dofetilide (250 mcg twice daily for 5 days) had no significant effect on the steady-state pharmacokinetics of digoxin (250 mcg once daily) in healthy volunteers compared to placebo.
MANAGEMENT: Clinicians should be aware of the potential for increased risk of torsade de pointes when dofetilide is administered in patients treated with digoxin.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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