Drug interactions between Depacon and fosphenytoin
| Results for the following 2 drugs: |
|---|
| Depacon (valproic acid) |
| fosphenytoin |
Interactions between your selected drugs
valproic acid ↔ fosphenytoin
Applies to:Depacon (valproic acid) and fosphenytoin
MONITOR: Valproic acid (and its derivatives) may increase the pharmacologic effects of phenytoin. Toxicity may result, despite normal phenytoin levels. The mechanism may be related to displacement of phenytoin from plasma proteins. Also, phenytoin may induce the CYP450 metabolism of valproic acid. Similar interactions may occur with other hydantoins.
MANAGEMENT: Patients on combination therapy should be closely monitored for clinical and laboratory evidence of altered phenytoin and valproate effects. It may be more useful to monitor plasma free-phenytoin levels than to monitor total plasma concentrations. Patients should be advised to notify their physician if they experience symptoms of toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia).
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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