Drug Interactions between deferasirox and zaleplon
This report displays the potential drug interactions for the following 2 drugs:
- deferasirox
- zaleplon
Interactions between your drugs
zaleplon deferasirox
Applies to: zaleplon and deferasirox
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of zaleplon. According to the prescribing information, CYP450 3A4 is a minor metabolizing enzyme of zaleplon. When zaleplon was coadministered with the potent CYP450 3A4 inducer rifampin (600 mg daily for 14 days), zaleplon plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 80%. The extent to which other, less potent CYP450 3A4 inducers may interact with zaleplon is unknown.
MANAGEMENT: Caution is advised when zaleplon is coadministered with CYP450 3A4 inducers. Monitoring for diminished therapeutic response to zaleplon is recommended.
References
- "Product Information. Sonata (zaleplon)." Wyeth-Ayerst Laboratories PROD (2001):
Drug and food interactions
zaleplon food
Applies to: zaleplon
Taking zaleplon with a high-fat or heavy meal may delay the onset of sleep. For faster sleep onset, zaleplon should not be administered with or immediately after a high-fat or heavy meal. This will make it easier for your body to absorb the medication. You should avoid the use of alcohol while being treated with zaleplon. Alcohol can increase the nervous system side effects of zaleplon such as dizziness and drowsiness. Some people may also experience impairment in thinking and judgment. Talk to your doctor or pharmacist if you have any questions or concerns.
deferasirox food
Applies to: deferasirox
You may experience reduced absorption of deferasirox in the presence of food. Take deferasirox on an empty stomach 30 minutes before eating preferably at the same time everyday unless otherwise directed by your doctor. This will make it easier for your body to absorb the medication. The tablets should not be chewed or swallowed whole. The tablets should first be completely dispersed in water, orange juice, or apple juice, and the resulting suspension drunk immediately. After swallowing the suspension any residue should be resuspended in a small volume of the liquid and swallowed.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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