Drug interactions between Cymbalta and Toviaz
| Results for the following 2 drugs: |
|---|
| Cymbalta (duloxetine) |
| Toviaz (fesoterodine) |
Interactions between your selected drugs
duloxetine ↔ fesoterodine
Applies to:Cymbalta (duloxetine) and Toviaz (fesoterodine)
MONITOR: Coadministration with inhibitors of CYP450 2D6 may increase the plasma concentrations of fesoterodine's active metabolite, 5-hydroxymethyl tolterodine, which is partially metabolized by the isoenzyme. The interaction has not been examined in pharmacokinetic studies. In poor metabolizers of CYP450 2D6, representing maximum CYP450 2D6 inhibition, 5-hydroxymethyl tolterodine peak plasma concentration (Cmax) and systemic exposure (AUC) are increased 1.7- and 2-fold, respectively, relative to extensive metabolizers.
MANAGEMENT: No initial dosing adjustments are recommended when fesoterodine is used in combination with CYP450 2D6 inhibitors. Patients should be advised to notify their physician if they experience potential adverse effects of fesoterodine such as irregular heartbeat, blurry vision, difficulty urinating, dry mouth, headache, drowsiness, dizziness, gastrointestinal upset, or constipation.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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