Drug interactions between cyclosporine and Zoloft
| Results for the following 2 drugs: |
|---|
| cyclosporine |
| Zoloft (sertraline) |
Interactions between your selected drugs
cyclosporine ↔ sertraline
Applies to:cyclosporine and Zoloft (sertraline)
MONITOR: The concomitant administration of sertraline and cyclosporine been associated with serotonin syndrome. The mechanism is unknown but may involve inhibition of CYP450 3A4 metabolism by cyclosporine. In a single case report, a 53-year-old renal transplant patient taking cyclosporine 100 mg twice daily developed symptoms of serotonin syndrome 5 days after sertraline 50 mg/day was added to his regimen. In addition, the combination has been associated with increased cyclosporine blood concentrations, although other concomitant drugs may have confounded the results. The mechanism may involve competition for CYP450 3A4-mediated metabolism, of which both drugs are substrates.
MANAGEMENT: Until more information is available, monitoring patients for adverse effects, and changes in cyclosporine concentrations and renal function may be advisable. Patients should be advised to notify their physician if they experience symptoms of cyclosporine toxicity (including nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache) or signs of excessive serotonergic activity (CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia).
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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