Drug Interactions between ConZip and difelikefalin

Using difelikefalin together with traMADol may increase nervous system side effects such as dizziness, somnolence, confusion, unsteadiness, and falls. You should avoid activities requiring mental alertness and motor coordination such as driving or operating hazardous machinery until you know how these medications affect you. Using both medications together may also cause greater increases in potassium blood levels than difelikefalin alone. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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