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Drug Interactions between Comtrex Nighttime Cold & Cough and house dust mite allergen extract

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

chlorpheniramine dextromethorphan

Applies to: Comtrex Nighttime Cold & Cough (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine) and Comtrex Nighttime Cold & Cough (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine)

Using chlorpheniramine together with dextromethorphan may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

chlorpheniramine house dust mite allergen extract

Applies to: Comtrex Nighttime Cold & Cough (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine) and house dust mite allergen extract

Using house dust mite allergen extract together with chlorpheniramine may not be advisable. Immunotherapy with house dust mite allergen extract can sometimes cause severe, even potentially life-threatening allergic reactions that require emergency treatment with epinephrine, and medications like chlorpheniramine can potentiate the body's response to epinephrine and significantly increase its effects on blood pressure and heart rate as well as serious and potentially fatal irregular heart rhythms. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

acetaminophen food

Applies to: Comtrex Nighttime Cold & Cough (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine)

Ask your doctor before using acetaminophen together with ethanol. This can cause serious side effects that affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

chlorpheniramine food

Applies to: Comtrex Nighttime Cold & Cough (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine)

Alcohol can increase the nervous system side effects of chlorpheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with chlorpheniramine. Do not use more than the recommended dose of chlorpheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

dextromethorphan food

Applies to: Comtrex Nighttime Cold & Cough (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine)

Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dextromethorphan. Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

house dust mite allergen extract food

Applies to: house dust mite allergen extract

Consuming food or beverage during or immediately after using house dust mite allergen extract may reduce the amount of allergen extract available for absorption from tissues under the tongue into the blood stream. Food or beverage should not be taken with, or for at least 5 minutes after, using house dust mite allergen extract. Use of alcohol with house dust mite allergen extract may increase the risk and severity of allergic reactions that can sometimes occur during treatment with house dust mite allergen extract. Potentially life-threatening or fatal reactions may occur. Talk to your doctor if you have any questions or concerns. Stop using house dust mite allergen extract, administer epinephrine, and seek immediate medical attention if signs and symptoms of an allergic reaction develop such as trouble breathing, swallowing, or speaking; throat tightness or swelling; dizziness, lightheadedness, or fainting; rapid or weak heartbeat; severe stomach cramps or pain; vomiting or diarrhea; and/or severe flushing or itching. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenylephrine food

Applies to: Comtrex Nighttime Cold & Cough (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine)

Both phenylephrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.