Drug interactions between codeine and Lexapro
Results for the following 2 drugs: |
|
|---|---|
| codeine | |
| Lexapro (escitalopram) | |
Interactions between your selected drugs
codeine ⇔ escitalopram
Applies to: codeine and Lexapro (escitalopram)
MONITOR: Drugs that are inhibitors of CYP450 2D6 may interfere with the analgesic effect of codeine. The mechanism is decreased in vivo conversion of codeine to morphine, a metabolic reaction mediated by CYP450 2D6.
MANAGEMENT: The possibility of reduced or inadequate pain relief should be considered in patients receiving codeine with drugs that inhibit CYP450 2D6. An increase in the codeine dosage or a different analgesic agent may be necessary in patients requiring therapy with CYP450 2D6 inhibitors.
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