Drug interactions between clonazepam and Parnate
| Results for the following 2 drugs: |
|---|
| clonazepam |
| Parnate (tranylcypromine) |
Interactions between your selected drugs
clonazepam ↔ tranylcypromine
Applies to:clonazepam and Parnate (tranylcypromine)
MONITOR: Limited clinical data suggest that the concomitant use of clonazepam and monoamine oxidase inhibitors (MAOIs) may precipitate a hypertensive and/or flushing reaction. The mechanism is unknown. Phenelzine has been specifically implicated in this interaction. Data for other combinations of MAOIs and benzodiazepines are not available.
MANAGEMENT: Until more is known about this potential interaction, patients should be monitored for development of hypertension during coadministration of clonazepam with an MAOI or other agents that possess MAOI activity (e.g., furazolidone, procarbazine). Patients should be advised to notify their physician if they develop severe headaches or flushing.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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