Drug interactions between clonazepam and Depakote ER
Results for the following 2 drugs: |
|
|---|---|
| clonazepam | |
| Depakote ER (divalproex sodium) | |
Interactions between your selected drugs
clonazepam ⇔ divalproex sodium
Applies to: clonazepam and Depakote ER (divalproex sodium)
MONITOR: A single study has suggested that combination therapy with clonazepam and valproic acid may cause severe drowsiness and decreased seizure control. Other studies have not supported this finding. Several case reports have suggested that the combination of clonazepam and valproic acid may precipitate absence status; however, this combination has had beneficial effects in the treatment refractory absence seizures. The mechanism and causality have not been determined. In addition, valproic acid may decrease plasma levels of clonazepam by inducing its hepatic metabolism.
MANAGEMENT: Monitoring for altered efficacy and safety is recommended if valproic acid (or its derivatives) and clonazepam are used together. Alternative therapy may be appropriate if significant side effects or loss of seizure control occur.
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