Drug interactions between chlorothiazide and Lasix
Results for the following 2 drugs: |
|
|---|---|
| chlorothiazide | |
| Lasix (furosemide) | |
Interactions between your selected drugs
furosemide ⇔ chlorothiazide
Applies to: Lasix (furosemide) and chlorothiazide
MONITOR: The combination of a thiazide and loop diuretic may produce additive or synergistic effects on diuresis and excretion of electrolytes including sodium, potassium, magnesium, and chloride. Although these agents may be combined therapeutically in some patients with inadequate response to a single agent, the increased risk of dehydration, hypotension, hypokalemia, hypomagnesemia, and hyponatremia should be recognized. The exact mechanism of interaction is unclear but appears to be pharmacodynamic rather than pharmacokinetic.
MANAGEMENT: Caution is advised during concomitant use of a thiazide and loop diuretic. Dosages should be titrated slowly and carefully, and electrolytes, BUN, fluid status, blood pressure, and renal function should be monitored regularly. Patients should be advised to contact their physician if they experience signs and symptoms of fluid and electrolyte depletion such as dizziness, lightheadedness, dry mouth, thirst, fatigue, weakness, lethargy, muscle cramps, decreased urination, postural hypotension, and tachycardia.
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