Drug interactions between Chloracol and Miradon
| Results for the following 2 drugs: |
|---|
| Chloracol (chloramphenicol) |
| Miradon (anisindione) |
Interactions between your selected drugs
chloramphenicol ↔ anisindione
Applies to:Chloracol (chloramphenicol) and Miradon (anisindione)
GENERALLY AVOID: Chloramphenicol may significantly increase the effects of oral anticoagulants. The proposed mechanism is inhibition of hepatic metabolism. Patients with vitamin K deficiencies may have a higher risk.
MANAGEMENT: These drugs should only be given concomitantly if benefit outweighs risk. If patients do receive this combination, they should be monitored for bleeding, the INR or prothrombin time should be monitored closely, and warfarin dosage should be decreased as necessary. Patients should be advised to promptly report any signs of unusual bleeding or bruising to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, vaginal bleeding, nosebleeds, bleeding of gums from brushing, red or brown urine, or red or black stools.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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