Drug interactions between Carbatrol and Topamax
Results for the following 2 drugs: |
|
|---|---|
| Carbatrol (carbamazepine) | |
| Topamax (topiramate) | |
Interactions between your selected drugs
carbamazepine ⇔ topiramate
Applies to: Carbatrol (carbamazepine) and Topamax (topiramate)
ADJUST DOSE: Carbamazepine, when coadministered with topiramate may lead to a 40% decrease in the plasma concentration of topiramate. The mechanism of action appears to be due to increased metabolism of topiramate.
MANAGEMENT: If dosages of topiramate have been adjusted up, reduction or withdrawal of carbamazepine during adjunctive therapy may require a downward dose adjustment of topiramate. No adjustment in carbamazepine dosage is required when topiramate adjunctive therapy is started. Patients should be monitored for seizure control and should be advised to notify their physician if seizure control worsens.
See also...
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2009 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
