Drug interactions between butalbital and metronidazole
Results for the following 2 drugs: |
|
|---|---|
| butalbital | |
| metronidazole | |
Interactions between your selected drugs
metronidazole ⇔ butalbital
Applies to: metronidazole and butalbital
ADJUST DOSE: Coadministration with a barbiturate may significantly decrease the plasma concentrations and pharmacologic effects of nitroimidazoles. The proposed mechanism is barbiturate induction of nitroimidazole metabolism via hepatic microsomal enzymes. The interaction has been reported with metronidazole and has been attributed to treatment failure in patients with trichomoniasis, giardiasis, or amebiasis given the normally recommended dosages of metronidazole while being treated concomitantly with phenobarbital. Significantly increased clearance and shortened half-life of metronidazole were demonstrated. In many cases, metronidazole dosage had to be doubled or even tripled to achieve a cure. No data are available for tinidazole.
MANAGEMENT: Patients treated concomitantly with a barbiturate may require a higher dosage of metronidazole to achieve a cure. Two- to threefold dosage increases are not uncommon. Pharmacologic response to metronidazole should be monitored and the dosage adjusted as necessary. Given its structural similarities to metronidazole, the same precaution may be applicable during therapy with tinidazole, although clinical data are lacking.
See also...
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2009 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
