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Drug Interactions between brinzolamide ophthalmic and zonisamide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

brinzolamide ophthalmic zonisamide

Applies to: brinzolamide ophthalmic and zonisamide

Talk to your doctor before using brinzolamide ophthalmic together with zonisamide. After brinzolamide ophthalmic is instilled into the eye, the medication can be absorbed into the bloodstream and cause some of the same effects as zonisamide. This may increase the risk and/or severity of side effects like drowsiness, dizziness, numbness, tingling, ringing in the ears, loss of appetite, nausea, vomiting, diarrhea, kidney stones, fever, and heat stroke. You should drink plenty of fluids while being treated with zonisamide, especially during exercise or prolonged exposure to warm temperatures. Let your doctor know if you experience sudden back pain, abdominal pain, blood in the urine, painful urination, numbness or tingling in the hands and feet, decreased sweating, or a rise in body temperature. Avoid driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

zonisamide food

Applies to: zonisamide

Alcohol can increase the nervous system side effects of zonisamide such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with zonisamide. Do not use more than the recommended dose of zonisamide, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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