Drug Interactions between belumosudil and calcium carbonate / magnesium hydroxide / simethicone
This report displays the potential drug interactions for the following 2 drugs:
- belumosudil
- calcium carbonate/magnesium hydroxide/simethicone
Interactions between your drugs
calcium carbonate belumosudil
Applies to: calcium carbonate / magnesium hydroxide / simethicone and belumosudil
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with gastric acid-reducing agents other than proton pump inhibitors (PPIs) may reduce the oral bioavailability of belumosudil. The mechanism of interaction has not been established. Concomitant use of the PPI rabeprazole decreased belumosudil peak plasma concentration (Cmax) and systemic exposure (AUC) by 87% and 80%, respectively, while coadministration of omeprazole decreased belumosudil Cmax and AUC by 68% and 47%, respectively, in healthy subjects. Data for other gastric acid-reducing agents are not available.
MANAGEMENT: The potential for diminished pharmacologic effects of belumosudil should be considered during coadministration with gastric acid-reducing agents other than PPIs. Other authorities recommend having a dosing interval of at least 12 hours between the latter and belumosudil (GB).
References
- (2024) "Product Information. Rezurock (belumosudil)." Sanofi
- (2024) "Product Information. Rezurock (belumosudil)." Kadmon Pharmaceuticals, 11/2023
magnesium hydroxide belumosudil
Applies to: calcium carbonate / magnesium hydroxide / simethicone and belumosudil
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with gastric acid-reducing agents other than proton pump inhibitors (PPIs) may reduce the oral bioavailability of belumosudil. The mechanism of interaction has not been established. Concomitant use of the PPI rabeprazole decreased belumosudil peak plasma concentration (Cmax) and systemic exposure (AUC) by 87% and 80%, respectively, while coadministration of omeprazole decreased belumosudil Cmax and AUC by 68% and 47%, respectively, in healthy subjects. Data for other gastric acid-reducing agents are not available.
MANAGEMENT: The potential for diminished pharmacologic effects of belumosudil should be considered during coadministration with gastric acid-reducing agents other than PPIs. Other authorities recommend having a dosing interval of at least 12 hours between the latter and belumosudil (GB).
References
- (2024) "Product Information. Rezurock (belumosudil)." Sanofi
- (2024) "Product Information. Rezurock (belumosudil)." Kadmon Pharmaceuticals, 11/2023
Drug and food interactions
calcium carbonate food
Applies to: calcium carbonate / magnesium hydroxide / simethicone
Calcium absorption may be increased by taking it with food. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption. Calcium may be taken with food to increase absorption. Consider spacing calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
belumosudil food
Applies to: belumosudil
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: Administration with food increases the oral bioavailability of belumosudil. The mechanism has not been described. Administration of belumosudil (200 mg single oral dose) in healthy subjects, with a fatty and calorie-rich meal (approximately half of the calories were contained in the fat) increased the mean belumosudil peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 120% and 100%, respectively, compared to administration under fasting conditions. The time to reach peak concentration (Tmax) was delayed by 30 minutes. Administration of oral belumosudil 200 mg once daily with food in patients with chronic graft-versus-host disease (chronic GVHD) lead to steady-state concentrations of the drug with an accumulation ration of 1.4.
MANAGEMENT: To ensure maximal oral absorption, belumosudil should be administered with a meal, every day at the same time.
References
- (2024) "Product Information. Rezurock (belumosudil)." Sanofi
- (2024) "Product Information. Rezurock (belumosudil)." Kadmon Pharmaceuticals, 11/2023
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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