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Drug Interactions between avapritinib and Prezista

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

darunavir avapritinib

Applies to: Prezista (darunavir) and avapritinib

Darunavir may significantly increase the blood levels of avapritinib. This may increase the risk and/or severity of serious side effects such as bleeding in the brain; cognitive impairment (forgetfulness, confusion, trouble thinking); changes in mood or behavior; hallucinations; fluid retention or swelling; and decreases in blood cell counts. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

avapritinib food

Applies to: avapritinib

Avapritinib should be taken on an empty stomach, one hour before or two hours after a meal. Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with avapritinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of avapritinib. This may increase the risk and/or severity of serious side effects such as bleeding in the brain; cognitive impairment (forgetfulness, confusion, trouble thinking); changes in mood or behavior; hallucinations; fluid retention or swelling; and decreases in blood cell counts. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

darunavir food

Applies to: Prezista (darunavir)

Food can enhance the levels of darunavir in your body. Take darunavir with food. The type of food does not matter. This will make it easier for your body to absorb the medication. Swallow the whole tablets with a drink such as water or milk. Do not chew the tablets. Darunavir must be always be taken together at the same time as another medication called ritonavir (Norvir).

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer