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Drug Interactions between avacopan and Skyrizi

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

risankizumab avacopan

Applies to: Skyrizi (risankizumab) and avacopan

Using risankizumab together with avacopan may increase the risk of serious infections. In addition, risankizumab may decrease the blood levels and effects of avacopan. You may need a dose adjustment if you have been receiving avacopan and are starting treatment with risankizumab. Likewise, if you have been receiving both medications, the dose of avacopan may need to be adjusted if risankizumab is discontinued. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the interaction, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Contact your doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

avacopan food

Applies to: avacopan

To ensure adequate absorption of the medication, avacopan should be taken with food. You should avoid or limit consumption of grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with avacopan unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of avacopan. This may increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, infections, and liver problems. You should seek immediate medical attention if you develop signs and symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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