Skip to main content

Drug Interactions between avacopan and DaunoXome

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

DAUNOrubicin liposomal avacopan

Applies to: DaunoXome (daunorubicin liposomal) and avacopan

Consumer information for this interaction is not currently available.

MONITOR: Concomitant use with avacopan oral capsules may increase the plasma concentrations of orally administered sensitive P-gp substrates with relatively low bioavailability, such as dabigatran etexilate. The mechanism has not been elucidated; however, avacopan oral capsules are formulated with the excipient PEG-40 hydrogenated castor oil (macrogolglycerol hydroxystearate), which may act as a P-gp inhibitor. Clinical data are not available.

MANAGEMENT: Caution is advised when avacopan oral capsules are used concomitantly with oral medications that are substrates of P-gp, particularly those with relatively low bioavailability or a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever avacopan capsules are added to or withdrawn from therapy.

References

  1. "Product Information. Tavneos (avacopan)." Vifor Pharma Pty Ltd (2023):

Drug and food interactions

Moderate

avacopan food

Applies to: avacopan

To ensure adequate absorption of the medication, avacopan should be taken with food. You should avoid or limit consumption of grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with avacopan unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of avacopan. This may increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, infections, and liver problems. You should seek immediate medical attention if you develop signs and symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer