Drug Interactions between aspirin / carisoprodol / codeine and nirogacestat
This report displays the potential drug interactions for the following 2 drugs:
- aspirin/carisoprodol/codeine
- nirogacestat
Interactions between your drugs
codeine carisoprodol
Applies to: aspirin / carisoprodol / codeine and aspirin / carisoprodol / codeine
Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Do not drink alcohol or self-medicate with these medications without your doctor's approval, and do not exceed the doses or frequency and duration of use prescribed by your doctor. Also, because these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed and motor coordination, you should avoid driving or operating hazardous machinery until you know how they affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
carisoprodol nirogacestat
Applies to: aspirin / carisoprodol / codeine and nirogacestat
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Coadministration with nirogacestat may decrease the plasma concentrations and therapeutic effects of drugs that are substrates of CYP450 2C19. The proposed mechanism is increased clearance due to nirogacestat-mediated induction of CYP450 2C19. According to the manufacturer, concomitant use of a sensitive CYP450 2C19 substrate following multiple doses of nirogacestat is predicted to decrease the plasma concentration of the substrate. However, no pharmacokinetic data are available from drug interaction studies.
MANAGEMENT: The manufacturer advises that concomitant use of nirogacestat with drugs that are substrates of CYP450 2C19, particularly sensitive substrates or those with a narrow therapeutic range, where decreased concentrations may lead to a significant reduction in efficacy, should generally be avoided. If coadministration is considered necessary, patients should be monitored for diminished therapeutic effects. Clinical and laboratory monitoring should be considered whenever nirogacestat is added to or withdrawn from therapy with these drugs, and the dosage of the CYP450 2C19 substrate drug adjusted as necessary.
References
- "Product Information. Ogsiveo (nirogacestat)." SpringWorks Therapeutics, Inc. (2023):
Drug and food interactions
nirogacestat food
Applies to: nirogacestat
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Grapefruit, grapefruit juice, Seville oranges, and starfruit may significantly increase the plasma concentrations and pharmacologic effects of nirogacestat. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in these fruits. Coadministration of multiple doses of nirogacestat (150 mg twice daily) with the moderate CYP450 3A4 inhibitors erythromycin and fluconazole are predicted to increase the AUC of nirogacestat by 2.73-fold and 3.18-fold, respectively. The interaction has not been studied with grapefruit, Seville oranges, or starfruit. In general, the effect of grapefruit juice is concentration-, dose- and preparation-dependent, and can vary widely among brands. Certain preparations of grapefruit juice (e.g., high dose, double strength) have sometimes demonstrated potent inhibition of CYP450 3A4, while other preparations (e.g., low dose, single strength) have typically demonstrated moderate inhibition. Increased systemic exposure to nirogacestat may increase the risk of adverse effects including diarrhea, ovarian toxicity, hepatotoxicity, electrolyte abnormalities, and non-melanoma skin cancers.
MANAGEMENT: Patients treated with nirogacestat should avoid consumption of grapefruit, grapefruit juice, Seville oranges, starfruit, or any supplement containing grapefruit.
References
- "Product Information. Ogsiveo (nirogacestat)." SpringWorks Therapeutics, Inc. (2023):
carisoprodol food
Applies to: aspirin / carisoprodol / codeine
Alcohol can increase the nervous system side effects of carisoprodol such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with carisoprodol. Do not use more than the recommended dose of carisoprodol, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
codeine food
Applies to: aspirin / carisoprodol / codeine
Do not use alcohol or medications that contain alcohol while you are receiving treatment with codeine. This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. With certain long-acting formulations of narcotic pain medication, consumption of alcohol may also cause rapid release of the drug, resulting in high blood levels that may be potentially lethal. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. Do not use more than the recommended dose of codeine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.
aspirin food
Applies to: aspirin / carisoprodol / codeine
Ask your doctor before using aspirin together with ethanol. Do not drink alcohol while taking aspirin. Alcohol can increase your risk of stomach bleeding caused by aspirin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
aspirin food
Applies to: aspirin / carisoprodol / codeine
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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