Drug Interactions between aspirin / caffeine / salicylamide and diroximel fumarate

Talk to your doctor before using aspirin together with salicylamide. Combining these medications may increase your risk of developing gastrointestinal ulcers and bleeding. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor immediately if you develop severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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The use of diroximel fumarate in combination with higher doses of aspirin, such as those used to relieve pain and inflammation, may increase the potential for kidney damage. Let your doctor know if you experience any signs or symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and/or irregular heart rhythm. You can also speak with your healthcare provider to see if an alternative pain reliever, such as acetaminophen, might be an option for you.

Lower doses of non-enteric coated aspirin (up to 325 mg) are sometimes taken about 30 minutes prior to diroximel fumarate to help reduce the occurrence and severity of flushing. This combination has not been evaluated for longer than 4 weeks. Let your doctor know if you experience any side effects that are particularly bothersome or do not improve during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Limited evidence suggests that diroximel fumarate may have the potential to cause kidney damage, and using it with other medications that can also affect the kidney, such as salicylamide, may increase the risk. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Let your doctor know if you experience signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and/or irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Information for this minor interaction is available on the professional version.