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Drug Interactions between artemether / lumefantrine and Fansidar

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

pyrimethamine sulfadoxine

Applies to: Fansidar (pyrimethamine / sulfadoxine) and Fansidar (pyrimethamine / sulfadoxine)

Using pyrimethamine together with sulfadoxine can increase your risk of anemias. Contact your doctor if you experience any changes in your blood test or if you feel weak or fatigued. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

pyrimethamine artemether

Applies to: Fansidar (pyrimethamine / sulfadoxine) and artemether / lumefantrine

Talk to your doctor before using artemether together with pyrimethamine. The safety and effectiveness of combining these medications in the treatment of malaria have not been studied extensively. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

pyrimethamine lumefantrine

Applies to: Fansidar (pyrimethamine / sulfadoxine) and artemether / lumefantrine

Consumer information for this interaction is not currently available.

GENERALLY AVOID: There are limited data on the safety and efficacy of artemether-lumefantrine in combination with other antimalarial agents.

MANAGEMENT: The manufacturer recommends that the concurrent use of artemether-lumefantrine with other antimalarials be avoided

References

  1. "Product Information. Coartem (artemether-lumefantrine)." Novartis Pharmaceuticals (2009):

Drug and food interactions

Moderate

lumefantrine food

Applies to: artemether / lumefantrine

Each dose of lumefantrine should be taken with food such as milk, infant formula, pudding, porridge, or broth. Food helps the medication get absorbed into the bloodstream, so the medication may not work as well when taken on an empty stomach. If unable to be swallowed whole, lumefantrine tablets may be crushed and mixed with one to two teaspoons of water in a clean container and consumed immediately after mixing. The container should then be rinsed with more water and the contents consumed. This should be followed by eating as soon as possible. Avoid drinking grapefruit juice during treatment with lumefantrine. Grapefruit juice can cause too much of the medication to be in the blood. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Antimalarials

Therapeutic duplication

The recommended maximum number of medicines in the 'antimalarials' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antimalarials' category:

  • artemether/lumefantrine
  • Fansidar (pyrimethamine/sulfadoxine)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer