Drug Interactions between amitriptyline and MigraTen
This report displays the potential drug interactions for the following 2 drugs:
- amitriptyline
- MigraTen (acetaminophen/caffeine/isometheptene mucate)
Interactions between your drugs
amitriptyline isometheptene mucate
Applies to: amitriptyline and MigraTen (acetaminophen / caffeine / isometheptene mucate)
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Tricyclic antidepressants (TCAs) may enhance the pressor response to sympathomimetic agents such as pseudoephedrine. The mechanism is TCA inhibition of norepinephrine reuptake in adrenergic neurons, resulting in increased stimulation of adrenergic receptors. This may increase the risk of adverse reactions such as hypertension, throbbing headache, tremor, palpitation, chest pain, and cardiac dysrhythmia.
MANAGEMENT: Sympathomimetic agents such as pseudoephedrine should preferably be avoided during therapy with tricyclic antidepressants. If concomitant use is necessary, caution is recommended and cardiovascular status including blood pressure, should be monitored closely.
References
- "Product Information. Elavil (amitriptyline)." Stuart Pharmaceuticals PROD (2002):
- "Product Information. Vivactil (protriptyline)." Merck & Co., Inc PROD (2001):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- wilcock a, twycross r "Midazolam for intractable hiccup." J Pain Symptom Manage 12 (1996): 59-61
- "Product Information. Advil Cold, Sinus and Flu Extra Strength (chlorpheniramine/ibuprofen/pseudoephedrine)." Pfizer Consumer Healthcare A Division of Pfizer Canada Inc (2020):
- "Product Information. Allegra-D (fexofenadine-pseudoephedrine)." Sanofi-Aventis (2022):
- "Product Information. Teva-Cotridin Expectorant (codeine/guaifenesin/pseudoephedrine/triprolidine)." Teva Canada Limited (2018):
- TGA. Therapeutic Goods Administration. Australian Drug Evaluation Committee "CORE PSEUDOEPHEDRINE PRODUCT INFORMATION https://www.tga.gov.au/sites/default/files/otc-template-pi-pseudoephedrine.rtf"
caffeine isometheptene mucate
Applies to: MigraTen (acetaminophen / caffeine / isometheptene mucate) and MigraTen (acetaminophen / caffeine / isometheptene mucate)
Consumer information for this interaction is not currently available.
MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.
MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.
References
- Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res 1 (1979): 45-52
- Cavanaugh JH, Griffith JD, Oates JA "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther 11 (1970): 656
- "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc PROD (2001):
- "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals PROD (2001):
- "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals PROD (2001):
- "Product Information. Focalin (dexmethylphenidate)." Mikart Inc (2001):
- "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company (2002):
Drug and food interactions
acetaminophen food
Applies to: MigraTen (acetaminophen / caffeine / isometheptene mucate)
Ask your doctor before using acetaminophen together with ethanol. This can cause serious side effects that affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
amitriptyline food
Applies to: amitriptyline
Ask your doctor before using amitriptyline together with ethanol, this can alter the effects of amitriptyline and cause increased side effects. Call the doctor if you experience uneven heartbeats, extreme drowsiness, confusion, agitation, vomiting, blurred vision, sweating, muscle stiffness, feeling light-headed, and seizures. You should be warned not to exceed recommended dosages, to avoid alcohol, and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
caffeine food
Applies to: MigraTen (acetaminophen / caffeine / isometheptene mucate)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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