Drug interactions between amiodarone and Mexitil
| Results for the following 2 drugs: |
|---|
| amiodarone |
| Mexitil (mexiletine) |
Interactions between your selected drugs
amiodarone ↔ mexiletine
Applies to:amiodarone and Mexitil (mexiletine)
ADJUST DOSE: Coadministration of amiodarone and mexiletine has been associated with an isolated case of torsade de pointes. The mechanism of interaction is unknown, as mexiletine has not been shown to prolong the QT interval of the electrocardiogram. In fact, mexiletine has been used in the treatment of torsade de pointes. A study of patients with supraventricular tachyarrhythmias treated with a combination of amiodarone and mexiletine or mexiletine alone found no evidence of a pharmacokinetic interaction. Some investigators have also reported on the safe and effective use of the combination.
MANAGEMENT: In general, the concurrent use of amiodarone with other antiarrhythmic agents should be reserved for patients with life-threatening ventricular arrhythmias who are incompletely responsive to a single agent or to amiodarone alone. If adding or transferring to amiodarone, the dosages of previously administered agents should be reduced by 30% to 50% several days after the addition of amiodarone, when onset of arrhythmia suppression should occur. The continued need for other antiarrhythmic agents should be evaluated after the effects of amiodarone have been established, and discontinuation should generally be attempted. If the combination is continued, patients should be monitored for adverse effects including conduction disturbances and exacerbation of tachyarrhythmias. In amiodarone-treated patients who require additional antiarrhythmic agents, the initial dosage of such agents should be approximately one-half the usual recommended dosage.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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