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Drug Interactions between amantadine and Stalevo 200

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

amantadine levodopa

Applies to: amantadine and Stalevo 200 (carbidopa / entacapone / levodopa)

Consumer information for this interaction is not currently available.

ADJUST DOSE: When used as an adjunct to levodopa-based therapy in the management of Parkinson's disease, amantadine may increase the risk of levodopa-related adverse events such as confusion, hallucinations, nightmares, and gastrointestinal disturbances. Psychotic reactions have been observed in patients receiving amantadine and levodopa. The mechanism of this interaction has not been established but may be related to a synergistic effect between amantadine and levodopa. Nevertheless, the combination has been used therapeutically for the management of dyskinesia in people with Parkinson's disease.

MANAGEMENT: Close monitoring is recommended whenever amantadine is added to levodopa-based therapy. An adjustment of the dose of levodopa may be needed.

References

  1. (2020) "Product Information. Carbidopa-Levodopa (carbidopa-levodopa)." Teva Pharmaceuticals USA
  2. (2020) "Product Information. Stalevo 50 (carbidopa/entacapone/levodopa)." Almatica Pharma Inc
  3. (2023) "Product Information. AA-Levocarb CR (carbidopa-levodopa)." AA Pharma Inc
  4. (2023) "Product Information. Lecado (co-careldopa)." Sandoz Ltd
  5. (2023) "Product Information. Lecigon (carbidopa/entacapone/levodopa)." Stada Pharmaceuticals Australia Pty Ltd
View all 5 references
Moderate

levodopa entacapone

Applies to: Stalevo 200 (carbidopa / entacapone / levodopa) and Stalevo 200 (carbidopa / entacapone / levodopa)

The side effects of levodopa may be increased when it is used in combination with entacapone. You may need a dose adjustment if you have been taking levodopa and are starting or stopping treatment with entacapone. Contact your doctor if your condition changes or if you experience movement difficulties, increased drowsiness, dizziness, lightheadedness, flushing, and/or fainting. Avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

levodopa food

Applies to: Stalevo 200 (carbidopa / entacapone / levodopa)

Alcohol can increase the nervous system side effects of levodopa such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with levodopa. You may experience reduced effectiveness of levodopa in the presence of foods or enteral (tube) feedings with a high protein content. This may make the symptoms of Parkinson's disease worse. Talk with your doctor or nutrition counselor about the best foods to eat while you are taking this medication. Contact your doctor if your condition changes.

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Moderate

entacapone food

Applies to: Stalevo 200 (carbidopa / entacapone / levodopa)

Alcohol can increase the nervous system side effects of entacapone such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with entacapone. Do not use more than the recommended dose of entacapone, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

levodopa food

Applies to: Stalevo 200 (carbidopa / entacapone / levodopa)

Levodopa and multivitamin with minerals should not be taken orally at the same time. Products that contain iron may interfere with the absorption of levodopa and reduce its effectiveness. You should separate the dosing of these medications by as much as possible. Contact your doctor if your Parkinson symptoms worsen. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Dopaminergic agents for parkinsonism

Therapeutic duplication

The recommended maximum number of medicines in the 'dopaminergic agents for parkinsonism' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'dopaminergic agents for parkinsonism' category:

  • amantadine
  • Stalevo 200 (carbidopa/entacapone/levodopa)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer