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Drug Interactions between alpelisib and leniolisib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

alpelisib leniolisib

Applies to: alpelisib and leniolisib

Leniolisib may increase the blood levels and effects of alpelisib. You may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as high blood glucose levels, diarrhea, rash, and abdominal pain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

alpelisib food

Applies to: alpelisib

Food significantly enhances the absorption of alpelisib. You should take each dose of alpelisib at the same time each day with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Talk to your doctor if you have questions or have difficulty taking alpelisib with food. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

leniolisib food

Applies to: leniolisib

Grapefruit juice may increase the blood levels of certain medications such as leniolisib. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with leniolisib. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Pi3k inhibitors

Therapeutic duplication

The recommended maximum number of medicines in the 'PI3K inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'PI3K inhibitors' category:

  • alpelisib
  • leniolisib

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer