Drug interactions between Adrucil and Oncovin
| Results for the following 2 drugs: |
|---|
| Adrucil (fluorouracil) |
| Oncovin (vincristine) |
Interactions between your selected drugs
fluorouracil ↔ vincristine
Applies to:Adrucil (fluorouracil) and Oncovin (vincristine)
Coadministration of fluorouracil and vincristine may lead to an earlier onset and/or increased severity of side effects. The mechanism of action is inhibition of the metabolism of both drugs by a hepatic cytochrome P-450 isoenzyme in the CYP 3A subfamily. The clinical significance of this interaction has not been established. If fluorouracil and vincristine are used concomitantly, caution and close observation are advised.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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