Drug interactions between Adapin and Atamet
| Results for the following 2 drugs: |
|---|
| Adapin (doxepin) |
| Atamet (carbidopa/levodopa) |
Interactions between your selected drugs
doxepin ↔ levodopa
Applies to:Adapin (doxepin) and Atamet (carbidopa/levodopa)
Tricyclic antidepressants may slightly reduce the serum concentrations of levodopa and carbidopa and reduce their effects. The mechanism may be related to slowed gastric emptying and increased gastric degradation. Anecdotal reports also suggest that coadministration of tricyclic antidepressants and levodopa or carbidopa may occasionally result in hypertensive episodes; however, causality was not clearly established. The mechanism is unknown. Until more information is available, it may be prudent to monitor patients for altered efficacy and safety.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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